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NIEHS

Innate Immunity Signal Transduction in Human Leukocytes

health  research  science  environment  north carolina  clinical  study  patient  human leukocytes  innate immunity signal transduction  volunteer  clinical study  recruitment  open study  Durham  Raleigh  RTP 

The Innate Immunity Signal Transduction in Human Leukocytes is a research study to determine the response of immune cells from the bloodstream.

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NIEHS

Environmental Risk Factors for the Development of Myositis in Military Personnel

health  research  science  environment  maryland  clinical  study  DC  patient  bethesda  myositis  environmental risk factors  military  volunteer  clinical study  recruitment  open study 

This study attempts to determine if environmental and geographic exposures may be related to the development of myositis during military service and to obtain an initial understanding of the possible mechanisms involved.

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NIEHS

Effect of Innate Immunity on the Inflammatory Response to Endotoxin

health  research  science  environment  north carolina  clinical  study  inflammation  patient  immune system  innate immunity  endotoxin  volunteer  clinical study  recruitment  open study  Durham  Raleigh  RTP 

Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation.

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NIEHS

The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease

health  research  science  arthritis  diabetes  environment  north carolina  clinical  study  stress  patient  dexamethasone  metabolic disease  glucocorticoid receptor snps  volunteer  hormones  clinical study  recruitment  open study  Durham 

NIEHS researchers theorize that changes in the surface proteins of cells called receptors may predispose people to diseases, such as heart disease, arthritis, and diabetes.

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NIEHS

The Role of TGF-Beta in Asthmatic Epithelial Cell Susceptibility to RSV Infection

health  research  science  asthma  environment  north carolina  clinical  study  patient  tgf-beta  rsv infection  volunteer  clinical study  recruitment  open study  Durham  Raleigh  RTP 

Asthma patients seem to be more prone to viral infections, and NIEHS scientists believe that the cells that line these patients' airways, cause this result by overproducing TGF-beta1, a protein that promotes viral growth.

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NIEHS

Studies in the Natural History & Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies

health  research  science  environment  maryland  clinical  study  DC  patient  bethesda  pathogenesis of childhood-onset  adult-onset  idiopathic inflammatory myopathies  volunteer  clinical study  recruitment  open study  myopathy 

This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their causes and the immune system changes and medical problems associated with them.

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NIEHS

Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders

health  research  science  environment  maryland  immune  clinical  study  DC  patient  bethesda  families with twins  systemic rheumatic disorders  pathogenic studies  rheumatic  volunteer  clinical study  recruitment  open study  autoimune 

The goal of this study is to examine the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, when one has an autoimmune disease and the other does not.

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NIEHS

Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing

health  research  science  environment  north carolina  clinical  study  patient  sample collection registry for quality control of biological and environmental specimens  volunteer  clinical study  recruitment  open study  Durham  Raleigh  RTP 

Researchers are interested in developing a registry protocol to obtain biologic and environmental samples anonymously from adult volunteers for use in laboratory tests and studies.

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NIEHS

Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage

health  research  science  environment  north carolina  clinical  study  patient  p53  dna damage  volunteer  clinical study  recruitment  open study  Durham  Raleigh  RTP  healthy volunteer 

The gene p53 suppresses cancer and inflammation in the body, and NIEHS investigators speculate that changes in p53 lead to changes in inflammation and the ability to repair DNA damage.

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NIEHS

Environmental Risk Factors for the Anti-Synthetase Syndrome – The MYORISK Study

health  research  science  environment  maryland  clinical  study  DC  patient  bethesda  anti-synthetase syndrome  myorisk study  chronic muscle weakness  volunteer  clinical study  recruitment  open study 

This study intends to investigate the genetic and environmental risk factors involved in the development of myositis, an autoimmune muscle disease that causes chronic muscle weakness.

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NIEHS

Personalized Environment and Genes Study (PEGS)

health  research  science  environment  north carolina  clinical  study  patient  environmental polymorphisms registry  epr  dna registry  volunteer  clinical study  recruitment  open study  Durham  Raleigh  RTP  healthy volunteer 

The Personalized Environment and Genes Study (PEGS), formerly the Environmental Polymorphisms Registry or EPR, is a long-term research project to collect health, exposure, medical and genetic data from a diverse group of people in North Carolina in the United States.

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NIH

Volunteer Story: John (amyotrophic lateral sclerosis (ALS))

als  story  sclerosis  volunteer  john  amyotrophic  lateral 

NINDS Clinical Director Dr. Avindra Nath meets with clinical trial participant Mr. John Michael. Dr. Nath and his research team are conducting an NIH study to better understand amyotrophic lateral sclerosis or ALS. In the video, Mr. Michael shares his experience as a trial participant while Dr. Nath discusses his research. “Ever since being diagnosed in January of ’14, I kind of made it a mission of mine to find out as much as I can, what’s available out there as treatments, trials, and just my way of giving back, whether it helps me directly or somebody who comes after me,” Mr. Michael says.

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NIEHS

E-Cigs and Smoking Study

health  research  science  environment  north carolina  tobacco  clinical  smoking  study  patient  tobacco exposure  e-cigs  volunteer  e-cigarette  clinical study  recruitment  open study  Durham  Raleigh  RTP 

According to the Centers for Disease Control and Prevention, cigarette smoking causes more than 480,000 deaths each year in the United States, which translates to causing nearly one of every five deaths.

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NIEHS

The CaREFREE Study: Calorie Restriction, Environment, and Fitness: Reproductive Effects Evaluation

health  research  science  osteoporosis  exercise  environment  north carolina  clinical  study  nutrition  patient  diet  fitness  calories  volunteer  clinical study  recruitment  open study  Durham  Raleigh 

Many women develop irregular menstrual cycles which may make it difficult to become pregnant and increase the risk of osteoporosis.

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